The prevalence and role of functional autoantibodies to angiotensin-converting-enzyme-2 in patients with systemic sclerosis.

Bartosz Miziołek Marcin SienczykRenata GrzywaAgnieszka Łupicka-SłowikEugeniusz KucharzPrzemysław KotylaBeata Bergler-Czop

Published in: Autoimmunity (2021)

Anti-ACE2 antibodies appear to be other functional autoantibodies with the potential to dysregulate the balance between Ang II and Ang-(1-7). They are non-specific for SSc and probably result from polyautoimmunity which affect some of SSc patients. Their occurrence in SSc settings may be associated with a severe depletion of plasma Ang-(1-7).

Keyphrases

angiotensin ii
angiotensin converting enzyme
systemic sclerosis
interstitial lung disease
end stage renal disease
systemic lupus erythematosus
ejection fraction
newly diagnosed
risk factors
peritoneal dialysis
risk assessment
early onset
prognostic factors
human health
patient reported
drug induced