Prophylactic Chemotherapy with Methotrexate Leucovorin in High-Risk Hydatidiform Mole.

This study concludes that prophylactic chemotherapy with MTX and leucovorin may be capable of reducing GTN, which supports the prescription of MTX in high-risk mole, especially in countries with limited resources. The toxicity of methotrexate can be reduced with the addition of leucovorin.<br />.