Intestinal Adipocytes Transdifferentiate into Myofibroblast-like Cells and Contribute to Fibrosis in Crohn's Disease.

Zhijun GengJing LiLugen ZuoXiaofeng ZhangLian WangYongsheng XiaJingjing YangLixia YinXue SongYueyue WangDamin ChaiMin DengYuanyuan GeRong WuJianguo Hu

Published in: Journal of Crohn's & colitis (2024)

Intestinal adipocytes transdifferentiate into myofibroblasts and participate in the intestinal fibrosis process in CD, possibly through LPS/TLR4/TGF-β signalling.

Keyphrases

adipose tissue
inflammatory response
transforming growth factor
toll like receptor
immune response
liver fibrosis
epithelial mesenchymal transition
anti inflammatory
nuclear factor