RUNX1 can mediate the glucose and O-GlcNAc-driven proliferation and migration of human retinal microvascular endothelial cells.

Xindan XingHanying WangTian NiuYan JiangXin ShiKun Liu

Published in: BMJ open diabetes research & care (2021)

The present study reveals that high glucose condition directly affects retinal endothelial cells (EC) function, and O-GlcNAc modification is critical for the proliferation and migration of HRMECs, RUNX1 may take part in this mechanism, and maybe the function of RUNX1 is related to its O-GlcNAc modification level, which provides a new perspective for studying the mechanism of RUNX1 in diabetic retinopathy.

Keyphrases

endothelial cells
diabetic retinopathy
high glucose
transcription factor
optical coherence tomography
vascular endothelial growth factor
type diabetes
metabolic syndrome
blood glucose
optic nerve
insulin resistance
weight loss