Dysregulation of miR-543 in Parkinson's disease: Impact on the neuroprotective gene SIRT1.
Mirte ScheperAnand IyerJasper J AninkLucia MesarosovaJames D MillsEleonora AronicaPublished in: Neuropathology and applied neurobiology (2022)
We validated SIRT1 as a target of miR-543 in the brain and showed its function as a potential biomarker. Our results highlight the idea that dysregulation of miR-543 in early PD white matter, resulting in the dysregulation of SIRT1, potentially influencing the early white matter changes observed in PD.