The Genomic Landscape of HIV-Associated Plasmablastic Lymphoma.

Published in: Blood cancer discovery (2020)

A combined whole-exome and targeted sequencing study of 110 cases of human immunodeficiency virus-associated plasmablastic lymphomas revealed a distinct landscape of genetic lesions for this lymphoma entity, including a particular role of mutations in STAT3 and other members of the JAK-STAT signaling pathway, and of the RAS family in its pathogenesis. See related article by Liu et al., p. 112.

Keyphrases

human immunodeficiency virus
antiretroviral therapy
single cell
hepatitis c virus
copy number
hiv infected
diffuse large b cell lymphoma
signaling pathway
hiv positive
hiv aids
hiv testing
epithelial mesenchymal transition
cell proliferation
pi k akt
genome wide
south africa
gene expression
dna methylation