Microstructural and Microvascular Phenotype of Sarcomere Mutation Carriers and Overt Hypertrophic Cardiomyopathy.
George JoyChristopher I KellyMatthew WebberIain PierceIrvin TehLouise McGrathPaula VelazquezRebecca K HughesHuafrin KotwalArka DasFiona ChanAthanasios BakalakosMassimiliano LorenziniKonstantinos SavvatisSaidi A MohiddinPeter W MacfarlaneMichele OriniCharlotte H ManistyPeter KellmanRhodri H DaviesPier D LambiaseChristopher T NguyenJurgen E SchneiderMaría Teresa Tomé-EstebanGabriella CapturErica Dall'ArmellinaJames C MoonLuis Rocha LopesPublished in: Circulation (2023)
Microstructural alteration and MVD occur in overt HCM and are different in G+ and G- patients. Both also occur in the absence of hypertrophy in sarcomeric mutation carriers, in whom changes are associated with electrocardiographic abnormalities. Measurable changes in myocardial microstructure and microvascular function are early-phenotype biomarkers in the emerging era of disease-modifying therapy.