αvβ3-Specific Gold Nanoparticles for Fluorescence Imaging of Tumor Angiogenesis.
Marc PretzeValeska von KiedrowskiRoswitha RungeRobert FreudenbergRené HübnerGüllü DavarciRalf SchirrmacherCarmen WänglerBjörn WänglerPublished in: Nanomaterials (Basel, Switzerland) (2021)
This paper reports on the development of tumor-specific gold nanoparticles (AuNPs) as theranostic tools intended for target accumulation and the detection of tumor angiogenesis via optical imaging (OI) before therapy is performed, being initiated via an external X-ray irradiation source. The AuNPs were decorated with a near-infrared dye, and RGD peptides as the tumor targeting vector for αvβ3-integrin, which is overexpressed in tissue with high tumor angiogenesis. The AuNPs were evaluated in an optical imaging setting in vitro and in vivo exhibiting favorable diagnostic properties with regards to tumor cell accumulation, biodistribution, and clearance. Furthermore, the therapeutic properties of the AuNPs were evaluated in vitro on pUC19 DNA and on A431 cells concerning acute and long-term toxicity, indicating that these AuNPs could be useful as radiosensitizers in therapeutic concepts in the future.
Keyphrases
- gold nanoparticles
- high resolution
- fluorescence imaging
- endothelial cells
- photodynamic therapy
- oxidative stress
- computed tomography
- magnetic resonance
- emergency department
- intensive care unit
- magnetic resonance imaging
- radiation therapy
- induced apoptosis
- quantum dots
- mass spectrometry
- single cell
- reduced graphene oxide
- radiation induced
- drug delivery
- single molecule
- endoplasmic reticulum stress
- nucleic acid
- real time pcr