A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms.
Robin F ChanWilliam E CopelandMin ZhaoLin Y XieJane CostelloKarolina A AbergEdwin J C G van den OordPublished in: Journal of child psychology and psychiatry, and allied disciplines (2021)
Our study suggests that the emergence of sex differences in depression may be related to the differential rewiring of brain circuits between boys and girls during puberty.