Short-term topiramate treatment prevents radiation-induced cytotoxic edema in preclinical models of breast-cancer brain metastasis.

Maria Jose Contreras-ZarateKaren L F Alvarez-ErasoJenny A Jaramillo-GómezZachary LittrellNikki TsujiD Ryan OrmondSana D KaramKabos PeterDiana M Cittelly

Published in: Neuro-oncology (2023)

Patients with BM could find additional benefits from acute and temporary preventive treatment of radiation-induced cytotoxic edema using anti-epileptic drugs able to block AQP4 function.

Keyphrases

radiation induced
radiation therapy
liver failure
intensive care unit
stem cells
respiratory failure
drug induced
multiple sclerosis
mesenchymal stem cells
bone marrow
white matter
cell therapy
brain injury
combination therapy
young adults
extracorporeal membrane oxygenation
childhood cancer