Antithyroid drug therapy in pregnancy and risk of congenital anomalies: Systematic review and meta-analysis.

Medha AgrawalSteffan LewisLakdasa D K E PremawardhanaColin M DayanPeter N Taylor Onyebuchi E Okosieme

Published in: Clinical endocrinology (2021)

ATD therapy carries a small risk of congenital anomalies which is higher for CMZ/MMI than for PTU and does not appear to be reduced by switching ATDs in pregnancy. Due to key limitations in the available data, further studies will be required to clarify the risks associated with untreated hyperthyroidism and with switching ATDs in pregnancy.

Keyphrases

preterm birth
pregnancy outcomes
machine learning
drug induced
data analysis
adverse drug