Chenodeoxycholic Acid Pharmacology in Biotechnology and Transplantable Pharmaceutical Applications for Tissue Delivery: An Acute Preclinical Study.
Armin MooranianCorina Mihaela IonescuSusbin Raj WagleBožica KovacevicDaniel WalkerMelissa JonesJacqueline ChesterEdan JohnstonMaja ĐanićMomir MikovCrispin R DassHani-Al SalamiPublished in: Cells (2021)
Islet encapsulation by PBA microcapsules did not compromise the microcapsules' morphology or features. Furthermore, the PBA-graft performed better in terms of glycemic control and resulted in modulation of the bile acid profile in the brain. This is suggestive that the improved glycemic control was mediated via brain-related effects. However, the improvement in graft insulin delivery and glycemic control was short-term.
Keyphrases
- glycemic control
- type diabetes
- blood glucose
- resting state
- white matter
- weight loss
- insulin resistance
- functional connectivity
- liver failure
- cerebral ischemia
- respiratory failure
- drug induced
- cell therapy
- multiple sclerosis
- mesenchymal stem cells
- hepatitis b virus
- bone marrow
- extracorporeal membrane oxygenation
- subarachnoid hemorrhage