Splenic sympathetic signaling contributes to acute neutrophil infiltration of the injured spinal cord.
Susana MonteiroAndreia G PinhoMara MacieiraCláudia Serre-MirandaJorge R CibrãoRui LimaCarina Soares-CunhaNatália L VasconcelosJosé Lentilhas-GraçaSara Duarte-SilvaAlice MirandaMargarida Correia-NevesAntónio J SalgadoNuno André SilvaPublished in: Journal of neuroinflammation (2020)
Collectively, our data demonstrates that the splenic sympathetic signaling is involved in the infiltration of neutrophils after spinal cord injury. Our findings give new mechanistic insights into the dysfunctional regulation of the inflammatory response mounted at the injured spinal cord.
Keyphrases
- spinal cord
- inflammatory response
- spinal cord injury
- neuropathic pain
- liver failure
- electronic health record
- respiratory failure
- lipopolysaccharide induced
- drug induced
- lps induced
- toll like receptor
- immune response
- extracorporeal membrane oxygenation
- intensive care unit
- acute respiratory distress syndrome
- mechanical ventilation