Fibroblast growth factor 23, endothelium biomarkers and acute kidney injury in critically-ill patients.

Fernanda Macedo de Oliveira NevesCamila Barbosa AraújoDaniele Ferreira de FreitasBianca Fernandes Távora ArrudaLeonardo José Monteiro de Macêdo FilhoVivian Brito SallesGdayllon Cavalcante MenesesAlice Maria Costa MartinsAlexandre Braga Libório

Published in: Journal of translational medicine (2019)

The association between FGF23 and AKI are mediated by endothelium-related biomarkers, mainly VCAM-1, AGPT2 and syndecan-1. Moreover, the statistical models show that syndecan-1, a biomarker of endothelial glycocalyx dysfunction, seems to be the initial mediator between FGF23 and severe AKI.

Keyphrases

acute kidney injury
nitric oxide
endothelial cells
oxidative stress
early onset
drug induced
cell adhesion