Autophagy and its role in osteosarcoma.
Biao NingYixin LiuTianhe HuangYongchang WeiPublished in: Cancer medicine (2023)
Osteosarcoma (OS) is the most common bone malignancy and preferably occurs in children and adolescents. Despite significant advances in surgery and chemotherapy for OS over the past few years, overall survival rates of OS have reached a bottleneck. Thus, extensive researches aimed at developing new therapeutic targets for OS are urgently needed. Autophagy, a conserved process which allows cells to recycle altered or unused organelles and cellular components, has been proven to play a critical role in multiple biological processes in OS. In this article, we summarized the association between autophagy and proliferation, metastasis, chemotherapy, radiotherapy, and immunotherapy of OS, revealing that autophagy-related genes and pathways could serve as potential targets for OS therapy.
Keyphrases
- cell death
- signaling pathway
- endoplasmic reticulum stress
- induced apoptosis
- oxidative stress
- locally advanced
- cell cycle arrest
- minimally invasive
- early stage
- radiation therapy
- coronary artery disease
- rectal cancer
- radiation induced
- mesenchymal stem cells
- acute coronary syndrome
- risk assessment
- atrial fibrillation
- human health
- percutaneous coronary intervention
- bone loss