Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation.
Jun-Qi YangKhalid W KalimYuan LiXin DuanPhuong NguyenGurjit K Khurana HersheyJohn KronerBrandy RuffLi ZhangNathan SalomonisMark RochmanTing WenYi ZhengFukun GuoPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)
Cdc42 is required for Th2 cell differentiation and allergic airway inflammation, and rational targeting Cdc42 may serve as a preventive but not therapeutic approach for asthma control.