Immunohistochemical assessment of HRAS Q61R mutations in breast adenomyoepitheliomas.
Fresia ParejaMichael S TossFelipe C GeyerEdaise M da SilvaMahsa VahdatiniaAna Paula M SebastiaoPier SelenicaAustin SzatrowskiMarcia EdelweissHannah Y WenRaluca MihaiZsuzsanna VargaMaria P FoschiniBrian P RubinIan O EllisSarat ChandarlapatyAchim A JungbluthEdi BrogiBritta WeigeltJorge Sergio Reis-FilhoEmad A RakhaPublished in: Histopathology (2021)
IHC analysis of RAS Q61R shows high specificity (100%) and moderate sensitivity (71%) for detection of HRAS Q61R mutations in breast AMEs, and appears not to detect HRAS Q61K mutations. IHC analysis of RAS Q61R may constitute a useful technique in the diagnostic workup of ER-negative AMEs.