Plasma neurofilament light levels correlate with white matter damage prior to Alzheimer's disease: results from ADNI.

Fardin NabizadehMohammad BalabandianMohammad Reza RostamiSamuel Berchi KankamFatemeh RanjbaranMahsa Pourhamzehnull null

Published in: Aging clinical and experimental research (2022)

Our findings revealed that the level of NFL in the blood is linked to WM alterations in MCI patients. Plasma NFL has the potential to be a biomarker for microstructural alterations. However, further longitudinal studies are necessary to validate the predictive role of plasma NFL in cognitive decline.

Keyphrases

cognitive decline
mild cognitive impairment
white matter
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
peritoneal dialysis
prognostic factors
multiple sclerosis
oxidative stress
risk assessment
patient reported outcomes
patient reported