Axial Spondyloarthritis: Reshape the Future-From the "2022 GISEA International Symposium".
Fausto SalaffiCesare SiragusanoAlessandra AlciatiGiulia CassoneSalvatore D'AngeloSerena GuiducciEnnio Giulio FavalliFabrizio ContiElisa GremeseFlorenzo IannoneRoberto CaporaliMarco SebastianiGian Franco FerraccioliGiovanni LapadulaFabiola AtzeniPublished in: Journal of clinical medicine (2022)
The term "axial spondyloarthritis" (axSpA) refers to a group of chronic rheumatic diseases that predominantly involve the axial skeleton and consist of ankylosing spondylitis, reactive arthritis, arthritis/spondylitis associated with psoriasis (PsA) and arthritis/spondylitis associated with inflammatory bowel diseases (IBD). Moreover, pain is an important and common symptom of axSpA. It may progress to chronic pain, a more complicated bio-psychosocial phenomena, leading to a significant worsening of quality of life. The development of the axSpA inflammatory process is grounded in the complex interaction between genetic (such as HLA B27), epigenetic, and environmental factors associated with a dysregulated immune response. Considering the pivotal contribution of IL-23 and IL-17 in axSpA inflammation, the inhibition of these cytokines has been evaluated as a potential therapeutic strategy. With this context, here we discuss the main pathogenetic mechanisms, therapeutic approaches and the role of pain in axSpA from the 2022 International GISEA/OEG Symposium.
Keyphrases
- ankylosing spondylitis
- chronic pain
- rheumatoid arthritis
- disease activity
- pain management
- immune response
- oxidative stress
- prostate cancer
- dna methylation
- gene expression
- neuropathic pain
- preterm infants
- mental health
- systemic lupus erythematosus
- toll like receptor
- risk assessment
- radical prostatectomy
- copy number
- human health
- inflammatory response
- current status
- gestational age
- patient reported
- atopic dermatitis