Characteristics and outcome of prostate cancer patients with overall biopsy Gleason score 3 + 4 = 7 and highest Gleason score 3 + 4 = 7 or > 3 + 4 = 7.
Esther I VerhoefCharlotte F KweldamIntan P KümmerlinDaan NieboerChris H BangmaLuca IncrocciTheodorus H van der KwastMonique J RoobolGeert J van LeendersPublished in: Histopathology (2018)
Among patients with overall GS 3 + 4 = 7, those with highest GS > 3 + 4 = 7 had worse clinicopathological features, but clinical outcome was not statistically significant. Therefore, the use of overall GS instead of highest GS for clinical decision-making is justified, potentially preventing overtreatment in prostate cancer patients.