AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatology.

Apostolia-Maria TsimberidouAntonis SklirisAlan ValentineJamie ShawUrsula HeringHenry Hiep VoTung On ChanRoger S ArmenJeffrey R CottrellJen Q PanPhilip N Tsichlis

Published in: Cell & bioscience (2022)

Our data elucidate the incidence and mechanisms of psychiatric AEs in patients treated with PI3K/AKT/mTOR inhibitors and emphasize the need for careful monitoring.

Keyphrases

mental health
signaling pathway
risk factors
cell proliferation
electronic health record
big data
machine learning
data analysis
deep learning