Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice.
Xiaoyi ZhengLauren E HigdonAlexandre GaudetManav ShahAngela BalistieriCatherine LiPatricia de NadaiLatha PalaniappanXiaoping YangBriana SantoBrandon GinleyXiaoxin X WangKomuraiah MyakalaPratima NallagatlaMoshe LeviPinaki SarderAvi Z RosenbergJonathan S MaltzmanNathalie de Freitas CairesVivek BhallaPublished in: Kidney360 (2022)
We demonstrate that, in DKD-susceptible mice, Esm-1 protects against diabetes-induced albuminuria and podocytopathy, possibly through select IFN signaling. Companion studies in patients with diabetes suggest a role of Esm-1 in human DKD.