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A Bayesian dose-finding design for outcomes evaluated with uncertainty.

Matthew J SchipperYing YuanJeremy Mg TaylorRandall K Ten HakenChristina TsienTheodore S Lawrence
Published in: Clinical trials (London, England) (2021)
Incorporating uncertainty in dose-limiting toxicity assessment can improve the performance of the continual reassessment method design.
Keyphrases
  • oxidative stress
  • type diabetes
  • adipose tissue
  • skeletal muscle
  • glycemic control
  • weight loss
  • oxide nanoparticles