Mycophenolic acid, the active form of mycophenolate mofetil, interferes with IRF7 nuclear translocation and type I IFN production by plasmacytoid dendritic cells.

Minoru ShigesakaTomoki ItoMuneo InabaKai ImaiHideki YamanakaYoshiko AzumaAkihiro TanakaHideki AmuroTohru NishizawaYonsu SonAtsushi SatakeYoshio OzakiShosaku Nomura

Published in: Arthritis research & therapy (2020)

Our data suggest that MPA can interrupt the vicious pathogenic spiral of autoimmune disorders by regulating the function of DC subsets. This work unveiled a novel mechanism for the therapeutic ability of MMF against SLE.

Keyphrases

dendritic cells
systemic lupus erythematosus
immune response
regulatory t cells
electronic health record
multiple sclerosis
disease activity
peripheral blood
big data
rheumatoid arthritis
drug induced
machine learning
artificial intelligence