Metabolic Profiling of Glioblastoma Stem Cells Reveals Pyruvate Carboxylase as a Critical Survival Factor and Potential Therapeutic Target.
Ophélie RenoultMélanie Laurent-BlondHala AwadaLisa OliverNoémie JoallandMikaël CroyalFrançois ParisCatherine GratasClaire PecqueurPublished in: Neuro-oncology (2024)
Our findings demonstrate the critical role of pyruvate carboxylase in GSC metabolism, survival and escape to etoposide. They also highlight pyruvate carboxylase as a therapeutic target to overcome therapy resistance in GBM.