Activated Ras/JNK driven Dilp8 in imaginal discs adversely affects organismal homeostasis during early pupal stage in Drosophila, a new checkpoint for development.

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2019)

Our results reveal early pupal stage as a novel Dilp8 mediated post-pupariation checkpoint and provide further evidence for interorgan signaling during development, wherein a peripheral tissue influences the CNS driven endocrine function.

Keyphrases

dna damage
cell cycle
signaling pathway
cell death
blood brain barrier
genome wide
induced apoptosis
wild type