Amylin/leptin synergy is absent in extreme obesity and not restored by calorie restriction-induced weight loss in rats.

James L TrevaskisC WittmerJ AthanacioP S GriffinD G ParkesJ D Roth

Published in: Obesity science & practice (2016)

Extreme obesity associated with leptin resistance perturbs amylin/leptin weight loss synergy in rats, which cannot be restored by pre-treatment weight loss.

Keyphrases

weight loss
bariatric surgery
roux en y gastric bypass
gastric bypass

climate change
weight gain
glycemic control
obese patients

diabetic rats
high glucose
type diabetes

metabolic syndrome
physical activity
combination therapy