Amylin/leptin synergy is absent in extreme obesity and not restored by calorie restriction-induced weight loss in rats.
James L TrevaskisC WittmerJ AthanacioP S GriffinD G ParkesJ D RothPublished in: Obesity science & practice (2016)
Extreme obesity associated with leptin resistance perturbs amylin/leptin weight loss synergy in rats, which cannot be restored by pre-treatment weight loss.