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Bacteroides acidifaciens drives a liver detox program.

Jingjing YuBixiang Zhang
Published in: Cell host & microbe (2024)
Alcohol-associated liver disease is a leading cause of chronic liver conditions, yet there are limited effective therapies. In this issue of Cell Host & Microbe, Shen et al. demonstrate that soluble dietary fiber enhances intestinal Bacteroides acidifaciens, which ameliorates alcohol-associated liver injury in mice by activating hepatic ornithine aminotransferase.
Keyphrases
  • liver injury
  • drug induced
  • alcohol consumption
  • single cell
  • signaling pathway
  • cell therapy
  • quality improvement
  • high fat diet induced
  • mouse model
  • mesenchymal stem cells
  • insulin resistance