Breast Cancer Cell-Derived Adenosine Enhances Generation and Suppressor Function of Human Adaptive Regulatory T Cells.

Magis MandapathilMirosław J SzczepańskiEdwin K JacksonStephan LangTheresa L Whiteside

Published in: Journal of personalized medicine (2021)

BrCa producing ADO (CD73+ TU) favor the induction of Tr1, which expresses CD39 and CD73, hydrolyzes ATP to ADO, and effectively suppresses anti-tumor immunity.

Keyphrases

regulatory t cells
endothelial cells
nk cells
signaling pathway
breast cancer risk