Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease.
Belén Callejón-LeblicSaida Sanchez-EspirillaCarolina Gotera-RiveraRafael SantanaIsabel Díaz-OlivaresJose Maria Marin TrigoCiro Casanova MacarioBorja García CosioAntonia FusterIngrid Solanes GarcíaJuan P de-TorresNuria Feu ColladoCarlos Cabrera LopezCarlos Antonio Amado DiagoAmparo Romero PlazaLuis Alejandro Padrón FraysseEduardo Márquez MartínMargarita Marín RoyoEva Balcells VilarnauAntonia Llunell CasanovasCristina Martínez GonzálezJuan Bautista Galdíz IturriCelia Lacárcel BautistaJosé Luis Gómez-ArizaAntonio Pereira-VegaLuis SeijoJosé Luis López-CamposGermán Peces-BarbaTamara García-BarreraPublished in: International journal of molecular sciences (2023)
Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- simultaneous determination
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- mass spectrometry
- ejection fraction
- heavy metals
- cystic fibrosis
- liquid chromatography
- prognostic factors
- squamous cell carcinoma
- peritoneal dialysis
- metal organic framework
- climate change
- high resolution
- risk assessment
- high resolution mass spectrometry