Essential Oil of Matricaria chamomilla Alleviate Psoriatic-Like Skin Inflammation by Inhibiting PI3K/Akt/mTOR and p38MAPK Signaling Pathway.
Guang ChenCaohua LvQing NieXin LiYinyi LvGuoyan LiaoShuangchun LiuWei-Wei GeJin-Guang ChenYunting DuPublished in: Clinical, cosmetic and investigational dermatology (2024)
MCEO inhibited inflammation in HaCaT keratinocytes induced by IL-22/TNF-α/LPS, the potential mechanisms associated with inhibiting excessive activation and crosstalk between PI3K/Akt/mTOR and p38MAPK pathways. MCEO ameliorated skin injury in IMQ-induced psoriatic-like skin inflammation of mice by downregulating the levels of inflammatory cytokines but not IL-17A. Thus, anti-inflammatory plant drugs with different targets with combined applications were a potential therapeutic strategy in psoriasis.
Keyphrases
- signaling pathway
- oxidative stress
- rheumatoid arthritis
- anti inflammatory
- wound healing
- soft tissue
- essential oil
- ankylosing spondylitis
- diabetic rats
- pi k akt
- type diabetes
- induced apoptosis
- high glucose
- cell proliferation
- high fat diet induced
- adipose tissue
- skeletal muscle
- systemic lupus erythematosus
- weight loss
- endothelial cells
- wild type