Inhibition of the CD40/CD40L complex protects mice against ALI-induced pancreas degradation.

Sofiane TariketHind Hamzeh-CognasseCharles-Antoine ArthaudSandrine LaradiThomas BourletPhilippe BerthelotOlivier GarraudFabrice Cognasse

Published in: Transfusion (2019)

This study supports the idea that several organs are exposed during ALI development, and particularly when such experimental ALI aims at mimicking transfusion-associated ALI; nevertheless, preventive treatment inhibiting CD40/CD40L (sCD40L) complex formation provides protection from lung disease as well as disease of other organs.

Keyphrases

cardiac surgery
signaling pathway
high fat diet induced
metabolic syndrome
combination therapy
insulin resistance