miR-486-5p protects against rat ischemic kidney injury and prevents the transition to chronic kidney disease and vascular dysfunction.

Adrianna Douvris Jose L Viñas Alex A GutsolJoseph ZimpelmannDylan Burger Kevin D Burns

Published in: Clinical science (London, England : 1979) (2024)

In rats, administration of miR-486-5p early after kidney IR prevents injury, and protects against CKD development and systemic endothelial dysfunction. These protective effects are associated with inhibition of endothelial ICAM-1 and occur despite reduction in eNOS. miR-486-5p holds promise for the prevention of ischemic AKI and its complications.

Keyphrases

chronic kidney disease
end stage renal disease
endothelial cells
oxidative stress
ischemia reperfusion injury
acute kidney injury
mouse model
cerebral ischemia
risk factors
big data
machine learning