SERPINA1 gene polymorphisms in a population-based ALSPAC cohort.

David S DeLucaEdita PoluziorovieneVaida TaminskieneSabine WrengerAlgirdas UtkusAlgirdas ValiulisTomas AlasevičiusJohn HendersonAndrew BushTobias WelteSabina JanciauskieneArunas Valiulis

Published in: Pediatric pulmonology (2019)

Analyzed SNPs in SERPINA1 are not associated with wheezing/asthma phenotypes. Only rs28929474, the most common pathologic SNP (Pi*Z) in the SERPINA1 gene, might be associated with a risk of developing school-age asthma without exhibiting preschool wheeze.

Keyphrases

genome wide
chronic obstructive pulmonary disease
lung function
allergic rhinitis
dna methylation
copy number
neoadjuvant chemotherapy
cystic fibrosis
squamous cell carcinoma
genetic diversity