Loss of ceramide synthase 5 inhibits the development of experimentally induced aortic valve stenosis.
Laurine ReeseSven Thomas NiepmannPhilip DüsingLea HänschkeThomas BeiertSebastian ZimmerGeorg NickenigReinhard BauerFelix JansenAndreas ZietzerPublished in: Acta physiologica (Oxford, England) (2024)
We conclude that CerS5 is an important mediator for the development of AVS in mice on WD and regulates critical pathophysiological hallmarks of AVS formation. CerS5 is therefore an interesting target for pharmacological therapy and merits further investigation.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- transcatheter aortic valve implantation
- aortic valve replacement
- aortic stenosis
- high glucose
- heart failure
- diabetic rats
- stem cells
- high fat diet induced
- coronary artery disease
- bone marrow
- metabolic syndrome
- adipose tissue
- insulin resistance
- ejection fraction
- wild type