Combined blockade of mTOR and p21-activated kinases pathways prevents tumour growth in KRAS-mutated colorectal cancer.

Stefania BelliAda PesapaneAlberto ServettoDaniela EspositoFabiana Napolitano Claudia Maria Ascione Alessandra AllottaNicola ZambranoFederica Zito MarinoRenato FrancoTeresa TroianiLuigi Formisano Roberto Bianco

Published in: British journal of cancer (2023)

In conclusion, our results suggest the simultaneous blockade of mTOR and Pak pathways as a promising alternative therapeutic strategy for patients affected by KRAS-mut colorectal cancer.

Keyphrases

end stage renal disease
wild type
ejection fraction
cell proliferation
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
patient reported outcomes