Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA.

Anthony Yan-Tang WuPonarulselvam SekarDuen-Yi HuangShu-Hao HsuChi-Ming ChanWan-Wan Lin

Published in: Journal of biomedical science (2023)

UVA exposure rapidly induces ROS-PARP-1-AMPK-autophagic flux and late lysosomal dysfunction. Pre-inducing AMPK activation can prevent cellular events caused by UVA and provide a new protective strategy in photo-oxidative stress and photo-retinopathy.

Keyphrases

cell death
oxidative stress
dna damage
skeletal muscle
dna repair
cell cycle arrest
protein kinase
ischemia reperfusion injury
electron transfer
endoplasmic reticulum stress
pi k akt