Calcium signaling in endocardial and epicardial ventricular myocytes from streptozotocin-induced diabetic rats.

Lina Tariq Al KuryVadym SydorenkoManal Ma SmailMuhammad A QureshiAnatoly ShmygolDimitrios PapandreouJaipaul SinghFrank Christopher Howarth

Published in: Journal of diabetes investigation (2020)

STZ-induced diabetes resulted in an increase in amplitude of Ca2+ transients in EPI and ENDO myocytes that was independent of the LTCC current. Such an effect can be attributed, at least in part, to the dysfunction of the Na+ /Ca2+ exchanger. Additional studies are warranted to improve our understanding of the regional impact of diabetes on Ca2+ signaling, which will facilitate the discovery of new targeted treatments for diabetic cardiomyopathy.

Keyphrases

diabetic rats
oxidative stress
type diabetes
cardiovascular disease
heart failure
glycemic control
left ventricular
small molecule
protein kinase
single cell
resting state
catheter ablation
case control
diabetic nephropathy