Cystic fibrosis transmembrane conductance regulator-dependent bicarbonate entry controls rat cardiomyocyte ATP release via pannexin1 through mitochondrial signalling and caspase activation.

Yongshun WangJunjun ZhaoYin CaiHeather J Ballard

Published in: Acta physiologica (Oxford, England) (2020)

During simulated ischaemia, CFTR-dependent bicarbonate entry stimulated ATP and cytochrome c release from mitochondria; in the cytoplasm, cytochrome c-activated caspase 3, which in turn activated Panx1, and ATP was released through the opened Panx1 channel.

Keyphrases

cystic fibrosis
cell death
oxidative stress
pseudomonas aeruginosa
induced apoptosis
lung function
transcription factor
angiotensin ii
reactive oxygen species
living cells
fluorescent probe
sensitive detection
signaling pathway
air pollution