Genetic and epigenetic analysis of hepatocellular adenomas with atypical morphological features.
Simon HaefligerJuergen HenchColm J O'RourkeNathalie Meyer-SchallerSarp UzunJoan SaldarriagaAchim WeberLuca MazzucchelliPhilip JermannStephan FrankJesper B AndersenLuigi TerraccianoChristine SempouxMatthias S MatterPublished in: Histopathology (2022)
In our series, mutational, DNA methylation, as well as CNV analyses, supported a relationship of atypical HCAs with nonatypical HCAs rather than with HCC. Therefore, in cases with difficult differential diagnosis between HCC and HCA, it might be advisable to perform targeted sequencing and/or combined methylation/copy number profiling.