Target site pharmacokinetics of doxycycline for rosacea in healthy volunteers is independent of the food effect.

Arindam PalPeter MatznellerAnirudh GautamZoe ÖsterreicherBeatrix WulkersdorferBirgit ReiterThomas StimpflMarkus Zeitlinger

Published in: British journal of clinical pharmacology (2018)

At steady state, doxycycline concentrations in the skin of fed and fasting healthy volunteers were comparable. Doxycycline's efficacy in rosacea is possibly due to considerable dermal accumulation of unbound doxycycline and is independent of the effect of food.

Keyphrases

wound healing
blood glucose
type diabetes
soft tissue
blood pressure
metabolic syndrome
adipose tissue
climate change