Increase in NO causes osteoarthritis and chondrocyte apoptosis and chondrocyte ERK plays a protective role in the process.
Qun ChenXibin KaoYan GaoJinghong ChenZhaoheng DongChen ChenPublished in: Molecular biology reports (2021)
The increase in nitric oxide occurs specifically in OA patients. ERK pathway may play a protective role on the NO-induced chondrocyte apoptosis, and inhibition of ERK pathway enhances the NO-induced apoptosis.