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Increase in NO causes osteoarthritis and chondrocyte apoptosis and chondrocyte ERK plays a protective role in the process.

Qun ChenXibin KaoYan GaoJinghong ChenZhaoheng DongChen Chen
Published in: Molecular biology reports (2021)
The increase in nitric oxide occurs specifically in OA patients. ERK pathway may play a protective role on the NO-induced chondrocyte apoptosis, and inhibition of ERK pathway enhances the NO-induced apoptosis.
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