Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model.
Rene A PosmaLeonie H VenemaTobias M HuijinkAndrie C WesterkampA Mireille A WesselsNynke J De VriesFrank DoesburgJ RoggeveldPetra J OttensDaan J TouwMaarten W NijstenHenri G D LeuveninkPublished in: BMJ open diabetes research & care (2021)
Metformin was secreted during NMP of both rat and porcine kidneys. Excretion of metformin decreased under increasing concentrations of metformin, which might be explained by saturation of metformin transporters rather than a self-inhibitory effect. It remains unknown whether a self-inhibitory effect contributes to metformin accumulation in humans with longer exposure times.