Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications.
Eng Leng SawJames T PearsonDaryl O SchwenkePujika Emani MunasingheHirotsugu TsuchimochiShruti RawalSean CoffeyPhilip DavisRichard BuntonIsabelle Van HoutYuko KaiMichael J A WilliamsYoshihiko KakinumaMartin FroniusRajesh G KatarePublished in: Cardiovascular diabetology (2021)
We provide the first evidence for dysregulation of the cardiac NNCS in DHD. Increased cardiac ACh is beneficial and a potential new therapeutic strategy to prevent or delay the development of DHD.