Prenatal chromosomal microarray testing of fetuses with ultrasound structural anomalies: A prospective cohort study of over 1000 consecutive cases.

Hsu P ChongSusan HamiltonFionnuala Mone Ka-Wang CheungFiona S TogneriRachel Katherine MorrisElizabeth Quinlan-JonesDenise WilliamsStephanie AllenDominic J McMullanMark David Kilby

Published in: Prenatal diagnosis (2019)

Prenatal aCGH is a useful diagnostic tool in the investigation of fetuses with a significantly elevated NT or structural anomaly. With time and experience, rates of pathogenic CNVs have increased, and VUS have reduced, supporting the prenatal application of increasingly high resolution aCGH platforms.

Keyphrases

pregnant women
high resolution
gestational age
magnetic resonance imaging
copy number
computed tomography
ultrasound guided
genome wide