Preparation of 5-Fluoropyrazoles from Pyrazoles and N-Fluorobenzenesulfonimide (NFSI).

Vitalina LevchenkoYurii V DmytrivAndriy V TymtsunikKonstantin LiubchakAlexander RudnichenkoAnton V MelnykStanislav Y VeselovychYurii V BorodulinOleksandr M OtsalyukAndrei A TolmachevPavel K Mykhailiuk

Published in: The Journal of organic chemistry (2018)

Facile synthesis of 5-fluoropyrazoles by direct fluorination of pyrazoles with N-fluorobenzenesulfonimide (NFSI) was elaborated. This approach was used to prepare the unsubstituted 5-fluoro-1 H-pyrazole, the known fungicide Penflufen, and many functionalized 5-fluoropyrazoles: building blocks for medicinal chemistry and agrochemistry.

Keyphrases

molecularly imprinted
positron emission tomography
molecular docking
quantum dots
computed tomography
mass spectrometry
simultaneous determination