The MAPT gene is differentially methylated in the progressive supranuclear palsy brain.
Vincent HuinVincent HuinDominique Caparros-LefebvreClaude-Alain MaurageCharles DuyckaertsEniko KovariFlorence PasquierValérie Buée-ScherrerJulien LabreucheHélène BehalLuc BuéeClaire-Marie DhaenensBernard SablonnièrePublished in: Movement disorders : official journal of the Movement Disorder Society (2016)
This exploratory study suggests that regions other than the constitutive promoter may be involved in microtubule-associated protein tau gene regulation in tauopathies and that intron 0 hypomethylation may be a specific epigenetic signature of PSP. These preliminary findings require confirmation. © 2016 International Parkinson and Movement Disorder Society.