Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure.
Arpan G MazumderAmélie M JuléDaniel SunPublished in: Molecular neurodegeneration (2023)
Our findings demonstrate an essential role for energy metabolism in the response of optic nerve astrocytes to elevated IOP, and contrary to expectations, neuroinflammation had a limited overall role. The transcriptional response profile is supportive of the notion that optic nerve astrocytes have a beneficial role in glaucoma. These previously uncharacterized transcriptional response of optic nerve astrocytes to injury reveal their functional diversity and a greater heterogeneity than previously appreciated.