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Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure.

Arpan G MazumderAmélie M JuléDaniel Sun
Published in: Molecular neurodegeneration (2023)
Our findings demonstrate an essential role for energy metabolism in the response of optic nerve astrocytes to elevated IOP, and contrary to expectations, neuroinflammation had a limited overall role. The transcriptional response profile is supportive of the notion that optic nerve astrocytes have a beneficial role in glaucoma. These previously uncharacterized transcriptional response of optic nerve astrocytes to injury reveal their functional diversity and a greater heterogeneity than previously appreciated.
Keyphrases
  • optic nerve
  • optical coherence tomography
  • traumatic brain injury
  • oxidative stress
  • lipopolysaccharide induced
  • dna methylation
  • inflammatory response
  • brain injury
  • subarachnoid hemorrhage
  • cerebral ischemia