Comparative clinical efficacy and safety of insulin glargine 300 U/mL (Toujeo) versus insulin glargine 100 U/mL in Type 2 and Type 1 diabetes mellitus: A systematic literature review and meta-analysis.

Shashank R JoshiGursharan SinghAshwani MarwahShivani MittraViraj R SuvarnaSandeep N Athalye

Published in: Diabetes, obesity & metabolism (2023)

Gla-100 and Gla-300 had comparable efficacy and safety profiles in both T1D and T2D populations. Gla-300 showed a lower risk of nocturnal and total hypoglycemia, significant in insulin-experienced/exposed patients with T2D. Patients on Gla-300 required significantly more units of insulin daily than the Gla-100 group to achieve equivalent efficacy. This article is protected by copyright. All rights reserved.

Keyphrases

glycemic control
type diabetes
end stage renal disease
weight loss
insulin resistance
newly diagnosed
ejection fraction
chronic kidney disease
blood pressure
obstructive sleep apnea
physical activity
prognostic factors
metabolic syndrome
adipose tissue
patient reported outcomes
sleep apnea