Studies in Zebrafish and Rat Models Support Dual Blockade of EP2 and EP4 (Prostaglandin E 2 Receptors Type 2 and 4) for Renoprotection in Glomerular Hyperfiltration and Albuminuria.

Aikaterini KourpaAngela SchulzEva Mangelsen Debora Kaiser-GrafNils KoppersMonika StollMichael RotheMichael BaderBettina PurfürstSéverine Kunz Thomas GladytzThoralf NiendorfSebastian BachmannKerim Mutig Juliane Bolbrinker Daniela Panakova Reinhold Kreutz

Published in: Hypertension (Dallas, Tex. : 1979) (2023)

in the development of albuminuria in GH and support the renoprotective potential of combined pharmacological blockade of EP2 and EP4 receptors. These data support further translational research to explore this therapeutic option and a possible role of circadian clock genes.

Keyphrases

genome wide
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